Wang Lab Research
Click the links below to learn more about the research that takes place at Wang Lab
Epigenetic therapy potentiates transposable element transcription to create tumor-enriched antigens in glioblastoma cells
Abstract: Inhibiting epigenetic modulators can transcriptionally reactivate transposable elements (TEs).…
Learn More (Link to external site)Regulatory transposable elements in theencyclopedia of DNA elements
Abstract: Transposable elements (TEs) comprise ~50% of our genome, but knowledge of how TEs affect genome…
Learn More (Link to external site)Cis-regulatory evolution of the recently expanded Ly49 gene family
Abstract: Comparative genomics has revealed the rapid expansion of multiple gene families involved in…
Learn More (Link to external site)LINE1 mediates long-range DNA interactions
Abstract: The impact of transposable elements (TEs) on gene regulatory networks and how they are governed…
Learn More (Link to external site)Towards targeting transposable elements for cancer therapy
Abstract: Transposable elements (TEs) represent almost half of the human genome. Historically deemed ‘junk…
Learn More (Link to external site)Using long-read CAGE sequencing to profile cryptic-promoter-derived transcripts and their contribution to the immunopeptidome
Abstract: Recent studies have shown that the noncoding genome can produce unannotated proteins as antigens…
Learn More (Link to external site)Modbed track: Visualization of modified bases in single-molecule sequencing
Abstract: Recent advances in long-read sequencing technologies have not only dramatically increased…
Learn More (Link to external site)Non-small Cell Lung Cancer Epigenomes Exhibit Altered DNA Methylation in Smokers and Never-smokers
Abstract: Epigenetic alterations are widespread in cancer and can complement genetic alterations to influence…
Learn More (Link to external site)Transposable elements in mammalian chromatin organization
Abstract: Transposable elements (TEs) are mobile DNA elements that comprise almost 50% of mammalian genomic…
Learn More (Link to external site)Comparing genomic and epigenomic features across species using the WashU Comparative Epigenome Browser
Abstract: Genome browsers have become an intuitive and critical tool to visualize and analyze genomic…
Learn More (Link to external site)Pan-cancer analysis identifies tumor-specific antigens derived from transposable elements
Abstract: Cryptic promoters within transposable elements (TEs) can be transcriptionally reactivated in tumors…
Learn More (Link to external site)Widespread contribution of transposable elements to the rewiring of mammalian 3D genomes
Abstract: Transposable elements (TEs) are major contributors of genetic material in mammalian genomes. These…
Learn More (Link to external site)Functional characterization of enhancer activity during a long terminal repeat's evolution
Abstract: Many transposable elements (TEs) contain transcription factor binding sites and are implicated as…
Learn More (Link to external site)Exploring genomic data coupled with 3D chromatin structures using the WashU Epigenome Browser
Three-dimensional (3D) genomic structures are vital for gene regulation and cell function1. High-throughput…
Learn More (Link to external site)Epigenomic landscape of zebrafish TEs
Abstract: Transposable elements (TEs) encode regulatory elements that impact gene expression in multiple…
Learn More (Link to external site)Genetic, epigenetic, and environmental mechanisms govern allele-specific gene expression
Abstract: Allele-specific expression (ASE) is a phenomenon in which one allele is preferentially expressed…
Learn More (Link to external site)The Human Pangenome Project: a global resource to map genomic diversity
Abstract: The human reference genome is the most widely used resource in human genetics and is due for a…
Learn More (Link to external site)WashU Epigenome Browser update 2022
Abstract: WashU Epigenome Browser (https://epigenomegateway.wustl.edu/browser/) is a web-based genomic data…
Learn More (Link to external site)A mouse-specific retrotransposon drives a conserved Cdk2ap1 isoform essential for development
Summary: Retrotransposons mediate gene regulation in important developmental and pathological processes.…
Learn More (Link to external site)Epigenetic dynamics shaping melanophore and iridophore cell fate in zebrafish
Abstract: Background: Zebrafish pigment cell differentiation provides an attractive model for studying cell…
Learn More (Link to external site)Common DNA methylation dynamics in endometriod adenocarcinoma and glioblastoma suggest universal epigenomic alterations in tumorigenesis
Abstract: Trends in altered DNA methylation have been defined across human cancers, revealing global loss of…
Learn More (Link to external site)Human placental cytotrophoblast epigenome dynamics over gestation and alterations in placental disease
Summary: The human placenta and its specialized cytotrophoblasts rapidly develop, have a compressed lifespan,…
Learn More (Link to external site)Transcript assembly improves expression quantification of transposable elements in single-cell RNA-seq data
Abstract: Transposable elements (TEs) are an integral part of the host transcriptome. TE-containing noncoding…
Learn More (Link to external site)Epigenomic differences in the human and chimpanzee genomes are associated with structural variation
Abstract: Structural variation (SV), including insertions and deletions (indels), is a primary mechanism of…
Learn More (Link to external site)Tissue-specific usage of transposable element-derived promoters in mouse development
Background: Transposable elements (TEs) are a significant component of eukaryotic genomes and play essential…
Learn More (Link to external site)Exploring the coronavirus pandemic with the WashU Virus Genome Browser
The WashU Virus Genome Browser is a web-based portal for efficient visualization of viral ‘omics’ data in the…
Learn More (Link to external site)Cellular diversity of the regenerating caudal fin
Abstract: Zebrafish faithfully regenerate their caudal fin after amputation. During this process, both…
Learn More (Link to external site)DeepH&M: Estimating single-CpG hydroxymethylation and methylation levels from enrichment and restriction enzyme sequencing methods
Abstract: Increased appreciation of 5-hydroxymethylcytosine (5hmC) as a stable epigenetic mark, which defines…
Learn More (Link to external site)Regenerating zebrafish fin epigenome is characterized by stable lineage-specific DNA methylation and dynamic chromatin accessibility
Abstract: Background: Zebrafish can faithfully regenerate injured fins through the formation of a blastema, a…
Learn More (Link to external site)Co-opted transposons help perpetuate conserved higher-order chromosomal structures
Abstract: Background: Transposable elements (TEs) make up half of mammalian genomes and shape genome…
Learn More (Link to external site)The epigenomic landscape of transposable elements across normal human development and anatomy
Abstract: Transposable elements (TEs) have deposited functional regulatory elements throughout the human…
Learn More (Link to external site)WashU Epigenome Browser update 2019
Abstract: The WashU Epigenome Browser (https://epigenomegateway.wustl.edu/) provides visualization,…
Learn More (Link to external site)Transposable elements drive widespread expression of oncogenes in human cancers
Abstract: Transposable elements (TEs) are an abundant and rich genetic resource of regulatory sequences1,2,3.…
Learn More (Link to external site)Epigenomic landscape of nicotinic receptor genes
Abstract: Background: Nicotinic acetylcholine receptors (nAChRs) play an important role in cellular…
Learn More (Link to external site)Functional cis-regulatory modules encoded by mouse-specific endogenous retrovirus
Abstract: Cis-regulatory modules contain multiple transcription factor (TF)-binding sites and integrate the…
Learn More (Link to external site)Epigenomic annotation of noncoding mutations identifies mutated pathways in primary liver cancer
Abstract: Evidence that noncoding mutation can result in cancer driver events is mounting. However, it is…
Learn More (Link to external site)Whole-Genome DNA Methylation Profiling Identifies Epigenetic Signatures of Uterine Carcinosarcoma
Abstract: Uterine carcinosarcoma (UCS) is a form of endometrial cancer simultaneously exhibiting…
Learn More (Link to external site)Developmental enhancers revealed by extensive DNA methylome maps of zebrafish early embryos
Abstract: DNA methylation undergoes dynamic changes during development and cell differentiation. Recent…
Learn More (Link to external site)Integrative analysis of 111 reference human epigenomes
Abstract: The reference human genome sequence set the stage for studies of genetic variation and its…
Learn More (Link to external site)Intermediate DNA methylation is a conserved signature of genome regulation Learn More
Abstract: The role of intermediate methylation states in DNA is unclear. Here, to comprehensively identify…
Learn More (Link to external site)Evolution of Epigenetic Regulation in Vertebrate Genomes
Empirical models of sequence evolution have spurred progress in the field of evolutionary genetics for…
Learn More (Link to external site)DNA Methylation Signatures of Embryonic Surface Ectoderm and Human Skin Cells
Companion website for the vertebrate surface ectoderm and human skin project.
Learn More (Link to external site)Widespread contribution of transposable elements to the innovation of gene regulatory networks
Abstract: Transposable elements (TEs) have been shown to contain functional binding sites for certain…
Learn More (Link to external site)Mapping of Variable DNA Methylation Across Multiple Cell Types
Abstract: DNA methylation is an important epigenetic modification involved in many biological processes and…
Learn More (Link to external site)Combining MeDIP-seq and MRE-seq to estimate single CpG methylation genome wide
Overview: No current assay of DNA methylation provides single-CpG resolution, comprehensive genome-wide…
Learn More (Link to external site)Jointly analyzing MeDIP-seq and MRE-seq data
Introduction: methyMnM was developed for jointly analyzing MeDIP-seq and MRE-seq data, which were derived…
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